3T0F
IspH:HMBPP (substrate) structure of the E126D mutant
Summary for 3T0F
| Entry DOI | 10.2210/pdb3t0f/pdb |
| Related | 3DNF 3F7T 3SZL 3SZO 3SZU 3T0G |
| Descriptor | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER, (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, ... (4 entities in total) |
| Functional Keywords | 3fe-4s iron-sulfur cluster, conserved cysteine, ipp and dmapp production final step, non-mevalonate pathway, substrate hmbpp, low activity, oxidoreductase |
| Biological source | Escherichia coli |
| Total number of polymer chains | 2 |
| Total formula weight | 73533.78 |
| Authors | Span, I.,Graewert, T.,Bacher, A.,Eisenreich, W.,Groll, M. (deposition date: 2011-07-20, release date: 2011-11-30, Last modification date: 2023-09-13) |
| Primary citation | Span, I.,Grawert, T.,Bacher, A.,Eisenreich, W.,Groll, M. Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis. J.Mol.Biol., 416:1-9, 2012 Cited by PubMed: 22137895DOI: 10.1016/j.jmb.2011.11.033 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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