3SZU

IspH:HMBPP complex structure of E126Q mutant

Summary for 3SZU

Entry DOI	10.2210/pdb3szu/pdb
Related	3DNF 3F7T 3SZL 3SZO 3T0F 3T0G
Descriptor	4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER, (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, ... (4 entities in total)
Functional Keywords	3fe-4s iron-sulfur cluster, conserved cysteine, ipp and dmapp production final step, non-mevalonate pathway, substrate hmbpp, oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	73559.87
Authors	Span, I.,Graewert, T.,Bacher, A.,Eisenreich, W.,Groll, M. (deposition date: 2011-07-19, release date: 2011-11-30, Last modification date: 2023-09-13)
Primary citation	Span, I.,Grawert, T.,Bacher, A.,Eisenreich, W.,Groll, M. Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis. J.Mol.Biol., 416:1-9, 2012 Cited by PubMed: 22137895 DOI: 10.1016/j.jmb.2011.11.033 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation