3SOM

crystal structure of human MMACHC

Summary for 3SOM

• Entry DOI: 10.2210/pdb3som/pdb
• Descriptor: Methylmalonic aciduria and homocystinuria type C protein, COBALAMIN, CITRATE ANION, ... (7 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, cblc, organic aciduria, inborn errors of metabolism, cobalamin, vitamin b12, cobalt(iii), oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q9Y4U1
• Total number of polymer chains: 16
• Total formula weight: 549021.51

Authors

Krojer, T.,Froese, D.S.,von Delft, F.,Muniz, J.R.,Gileadi, C.,Vollmar, M.,Bountra, C.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Gravel, R.A.,Yue, W.W.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2011-06-30, release date: 2011-07-27, Last modification date: 2015-04-15)

• Primary citation: Froese, D.S.,Krojer, T.,Wu, X.,Shrestha, R.,Kiyani, W.,von Delft, F.,Gravel, R.A.,Oppermann, U.,Yue, W.W.; Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.; Biochemistry, 51:5083-5090, 2012; PubMed: 22642810; DOI: 10.1021/bi300150y

Experimental method

X-RAY DIFFRACTION (2.4 Å)