Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3SOM

crystal structure of human MMACHC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006749	biological_process	glutathione metabolic process
A	0009235	biological_process	cobalamin metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0031419	molecular_function	cobalamin binding
A	0032451	molecular_function	demethylase activity
A	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
A	0042803	molecular_function	protein homodimerization activity
A	0043295	molecular_function	glutathione binding
A	0055114	biological_process	obsolete oxidation-reduction process
A	0070988	biological_process	demethylation
A	0071949	molecular_function	FAD binding
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006749	biological_process	glutathione metabolic process
B	0009235	biological_process	cobalamin metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0031419	molecular_function	cobalamin binding
B	0032451	molecular_function	demethylase activity
B	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
B	0042803	molecular_function	protein homodimerization activity
B	0043295	molecular_function	glutathione binding
B	0055114	biological_process	obsolete oxidation-reduction process
B	0070988	biological_process	demethylation
B	0071949	molecular_function	FAD binding
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006749	biological_process	glutathione metabolic process
C	0009235	biological_process	cobalamin metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0031419	molecular_function	cobalamin binding
C	0032451	molecular_function	demethylase activity
C	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
C	0042803	molecular_function	protein homodimerization activity
C	0043295	molecular_function	glutathione binding
C	0055114	biological_process	obsolete oxidation-reduction process
C	0070988	biological_process	demethylation
C	0071949	molecular_function	FAD binding
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006749	biological_process	glutathione metabolic process
D	0009235	biological_process	cobalamin metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0031419	molecular_function	cobalamin binding
D	0032451	molecular_function	demethylase activity
D	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
D	0042803	molecular_function	protein homodimerization activity
D	0043295	molecular_function	glutathione binding
D	0055114	biological_process	obsolete oxidation-reduction process
D	0070988	biological_process	demethylation
D	0071949	molecular_function	FAD binding
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006749	biological_process	glutathione metabolic process
E	0009235	biological_process	cobalamin metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016740	molecular_function	transferase activity
E	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
E	0031419	molecular_function	cobalamin binding
E	0032451	molecular_function	demethylase activity
E	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
E	0042803	molecular_function	protein homodimerization activity
E	0043295	molecular_function	glutathione binding
E	0055114	biological_process	obsolete oxidation-reduction process
E	0070988	biological_process	demethylation
E	0071949	molecular_function	FAD binding
F	0005515	molecular_function	protein binding
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006749	biological_process	glutathione metabolic process
F	0009235	biological_process	cobalamin metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016740	molecular_function	transferase activity
F	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
F	0031419	molecular_function	cobalamin binding
F	0032451	molecular_function	demethylase activity
F	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
F	0042803	molecular_function	protein homodimerization activity
F	0043295	molecular_function	glutathione binding
F	0055114	biological_process	obsolete oxidation-reduction process
F	0070988	biological_process	demethylation
F	0071949	molecular_function	FAD binding
G	0005515	molecular_function	protein binding
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006749	biological_process	glutathione metabolic process
G	0009235	biological_process	cobalamin metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016740	molecular_function	transferase activity
G	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
G	0031419	molecular_function	cobalamin binding
G	0032451	molecular_function	demethylase activity
G	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
G	0042803	molecular_function	protein homodimerization activity
G	0043295	molecular_function	glutathione binding
G	0055114	biological_process	obsolete oxidation-reduction process
G	0070988	biological_process	demethylation
G	0071949	molecular_function	FAD binding
H	0005515	molecular_function	protein binding
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006749	biological_process	glutathione metabolic process
H	0009235	biological_process	cobalamin metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016740	molecular_function	transferase activity
H	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
H	0031419	molecular_function	cobalamin binding
H	0032451	molecular_function	demethylase activity
H	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
H	0042803	molecular_function	protein homodimerization activity
H	0043295	molecular_function	glutathione binding
H	0055114	biological_process	obsolete oxidation-reduction process
H	0070988	biological_process	demethylation
H	0071949	molecular_function	FAD binding
I	0005515	molecular_function	protein binding
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006749	biological_process	glutathione metabolic process
I	0009235	biological_process	cobalamin metabolic process
I	0016491	molecular_function	oxidoreductase activity
I	0016740	molecular_function	transferase activity
I	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
I	0031419	molecular_function	cobalamin binding
I	0032451	molecular_function	demethylase activity
I	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
I	0042803	molecular_function	protein homodimerization activity
I	0043295	molecular_function	glutathione binding
I	0055114	biological_process	obsolete oxidation-reduction process
I	0070988	biological_process	demethylation
I	0071949	molecular_function	FAD binding
J	0005515	molecular_function	protein binding
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006749	biological_process	glutathione metabolic process
J	0009235	biological_process	cobalamin metabolic process
J	0016491	molecular_function	oxidoreductase activity
J	0016740	molecular_function	transferase activity
J	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
J	0031419	molecular_function	cobalamin binding
J	0032451	molecular_function	demethylase activity
J	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
J	0042803	molecular_function	protein homodimerization activity
J	0043295	molecular_function	glutathione binding
J	0055114	biological_process	obsolete oxidation-reduction process
J	0070988	biological_process	demethylation
J	0071949	molecular_function	FAD binding
K	0005515	molecular_function	protein binding
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006749	biological_process	glutathione metabolic process
K	0009235	biological_process	cobalamin metabolic process
K	0016491	molecular_function	oxidoreductase activity
K	0016740	molecular_function	transferase activity
K	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
K	0031419	molecular_function	cobalamin binding
K	0032451	molecular_function	demethylase activity
K	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
K	0042803	molecular_function	protein homodimerization activity
K	0043295	molecular_function	glutathione binding
K	0055114	biological_process	obsolete oxidation-reduction process
K	0070988	biological_process	demethylation
K	0071949	molecular_function	FAD binding
L	0005515	molecular_function	protein binding
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006749	biological_process	glutathione metabolic process
L	0009235	biological_process	cobalamin metabolic process
L	0016491	molecular_function	oxidoreductase activity
L	0016740	molecular_function	transferase activity
L	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
L	0031419	molecular_function	cobalamin binding
L	0032451	molecular_function	demethylase activity
L	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
L	0042803	molecular_function	protein homodimerization activity
L	0043295	molecular_function	glutathione binding
L	0055114	biological_process	obsolete oxidation-reduction process
L	0070988	biological_process	demethylation
L	0071949	molecular_function	FAD binding
M	0005515	molecular_function	protein binding
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006749	biological_process	glutathione metabolic process
M	0009235	biological_process	cobalamin metabolic process
M	0016491	molecular_function	oxidoreductase activity
M	0016740	molecular_function	transferase activity
M	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
M	0031419	molecular_function	cobalamin binding
M	0032451	molecular_function	demethylase activity
M	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
M	0042803	molecular_function	protein homodimerization activity
M	0043295	molecular_function	glutathione binding
M	0055114	biological_process	obsolete oxidation-reduction process
M	0070988	biological_process	demethylation
M	0071949	molecular_function	FAD binding
N	0005515	molecular_function	protein binding
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006749	biological_process	glutathione metabolic process
N	0009235	biological_process	cobalamin metabolic process
N	0016491	molecular_function	oxidoreductase activity
N	0016740	molecular_function	transferase activity
N	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
N	0031419	molecular_function	cobalamin binding
N	0032451	molecular_function	demethylase activity
N	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
N	0042803	molecular_function	protein homodimerization activity
N	0043295	molecular_function	glutathione binding
N	0055114	biological_process	obsolete oxidation-reduction process
N	0070988	biological_process	demethylation
N	0071949	molecular_function	FAD binding
O	0005515	molecular_function	protein binding
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006749	biological_process	glutathione metabolic process
O	0009235	biological_process	cobalamin metabolic process
O	0016491	molecular_function	oxidoreductase activity
O	0016740	molecular_function	transferase activity
O	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
O	0031419	molecular_function	cobalamin binding
O	0032451	molecular_function	demethylase activity
O	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
O	0042803	molecular_function	protein homodimerization activity
O	0043295	molecular_function	glutathione binding
O	0055114	biological_process	obsolete oxidation-reduction process
O	0070988	biological_process	demethylation
O	0071949	molecular_function	FAD binding
P	0005515	molecular_function	protein binding
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006749	biological_process	glutathione metabolic process
P	0009235	biological_process	cobalamin metabolic process
P	0016491	molecular_function	oxidoreductase activity
P	0016740	molecular_function	transferase activity
P	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
P	0031419	molecular_function	cobalamin binding
P	0032451	molecular_function	demethylase activity
P	0033787	molecular_function	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity
P	0042803	molecular_function	protein homodimerization activity
P	0043295	molecular_function	glutathione binding
P	0055114	biological_process	obsolete oxidation-reduction process
P	0070988	biological_process	demethylation
P	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	BINDING SITE FOR RESIDUE B12 A 301

Chain	Residue
A	LEU34
A	HIS122
A	TYR129
A	GLN131
A	ARG144
A	SER146
A	CYS149
A	ILE160
A	PHE196
A	TRP200
A	TYR205
A	LEU35
A	HOH284
A	HOH290
A	HOH373
A	FLC501
A	HOH550
A	HOH585
A	HOH596
A	HOH758
A	HOH820
A	HOH881
A	PRO36
A	HOH1149
B	ARG111
B	5AD401
A	ASP104
A	PRO113
A	ILE115
A	ALA117
A	GLN118
A	THR119

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE FLC A 501

Chain	Residue
A	PHE158
A	ARG161
A	ARG206
A	TYR215
A	PHE223
A	ARG230
A	B12301
A	HOH547
A	HOH706
A	HOH845
B	5AD401

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DHL A 601

Chain	Residue
A	CYS182
A	VAL209

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 5AD A 401

Chain	Residue
A	PRO109
A	ASN110
A	ARG111
A	HOH833
B	B12301
B	FLC501
B	HOH576

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 5AD B 401

Chain	Residue
A	B12301
A	FLC501
A	HOH645
B	PRO109
B	ASN110
B	ARG111

site_id	AC6
Number of Residues	29
Details	BINDING SITE FOR RESIDUE B12 B 301

Chain	Residue
A	ARG111
A	5AD401
B	LEU34
B	LEU35
B	PRO36
B	ASP104
B	PRO113
B	ILE115
B	ALA117
B	GLN118
B	THR119
B	HIS122
B	TYR129
B	GLN131
B	ARG144
B	SER146
B	CYS149
B	ILE160
B	PHE196
B	TRP200
B	TYR205
B	HOH288
B	HOH289
B	HOH416
B	FLC501
B	HOH827
B	HOH831
B	HOH980
B	HOH987

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE FLC B 501

Chain	Residue
A	5AD401
B	VAL79
B	PHE158
B	ARG161
B	ARG206
B	TYR215
B	PHE223
B	ARG230
B	B12301
B	HOH580
B	HOH613
B	HOH785

site_id	AC8
Number of Residues	30
Details	BINDING SITE FOR RESIDUE B12 C 301

Chain	Residue
C	LEU34
C	LEU35
C	PRO36
C	ASP104
C	PRO113
C	ILE115
C	ALA117
C	GLN118
C	THR119
C	HIS122
C	TYR129
C	GLN131
C	ARG144
C	SER146
C	CYS149
C	ILE160
C	PHE196
C	TRP200
C	HOH283
C	HOH287
C	HOH368
C	FLC501
C	HOH536
C	HOH606
C	HOH791
C	HOH964
C	HOH1166
C	HOH1365
D	ARG111
D	5AD401

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FLC C 501

Chain	Residue
C	PHE158
C	ARG161
C	ARG206
C	TYR215
C	PHE223
C	ARG230
C	B12301
D	5AD401

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DHL C 601

Chain	Residue
C	PRO152
C	CYS182

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 5AD C 401

Chain	Residue
C	PRO109
C	ASN110
C	ARG111
C	HOH1613
D	B12301
D	HOH498
D	FLC501

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 5AD D 401

Chain	Residue
C	B12301
C	HOH413
C	FLC501
D	PRO109
D	ASN110
D	ARG111

site_id	BC4
Number of Residues	32
Details	BINDING SITE FOR RESIDUE B12 D 301

Chain	Residue
C	ARG111
C	5AD401
D	LEU34
D	LEU35
D	PRO36
D	ASP104
D	PRO113
D	ILE115
D	ALA117
D	GLN118
D	THR119
D	HIS122
D	TYR129
D	GLN131
D	ARG144
D	SER146
D	CYS149
D	ILE160
D	PHE196
D	TRP200
D	TYR205
D	HOH303
D	HOH304
D	HOH312
D	HOH346
D	HOH493
D	FLC501
D	HOH559
D	HOH584
D	HOH830
D	HOH914
D	HOH1033

site_id	BC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE FLC D 501

Chain	Residue
C	5AD401
D	PHE158
D	ARG161
D	ARG206
D	TYR215
D	PHE223
D	ARG230
D	HOH284
D	B12301
D	HOH377
D	HOH667

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DHL D 601

Chain	Residue
D	PRO152
D	CYS182
D	VAL209

site_id	BC7
Number of Residues	32
Details	BINDING SITE FOR RESIDUE B12 E 301

Chain	Residue
E	LEU34
E	LEU35
E	PRO36
E	ASP104
E	PRO113
E	ILE115
E	ALA117
E	GLN118
E	THR119
E	HIS122
E	TYR129
E	GLN131
E	ARG144
E	SER146
E	CYS149
E	ILE160
E	PHE196
E	TRP200
E	TYR205
E	EDO283
E	HOH285
E	HOH289
E	HOH293
E	HOH295
E	HOH356
E	FLC501
E	HOH582
E	HOH657
E	HOH757
E	HOH1019
E	HOH1110
F	5AD401

site_id	BC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC E 501

Chain	Residue
E	PHE158
E	ARG161
E	ARG206
E	TYR215
E	PHE223
E	ARG230
E	HOH290
E	B12301
E	HOH632
F	5AD401

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 5AD E 401

Chain	Residue
E	PRO109
E	ASN110
E	ARG111
F	HOH293
F	B12301
F	FLC501

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO E 283

Chain	Residue
E	LEU34
E	LEU35
E	PRO36
E	B12301

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 5AD F 401

Chain	Residue
E	HOH287
E	B12301
E	FLC501
F	PRO109
F	ASN110
F	ARG111

site_id	CC3
Number of Residues	31
Details	BINDING SITE FOR RESIDUE B12 F 301

Chain	Residue
E	5AD401
F	LEU34
F	LEU35
F	PRO36
F	ASP104
F	PRO113
F	ILE115
F	ALA117
F	GLN118
F	THR119
F	HIS122
F	TYR129
F	GLN131
F	ARG144
F	SER146
F	CYS149
F	ILE160
F	PHE196
F	TRP200
F	HOH283
F	HOH285
F	HOH286
F	HOH288
F	HOH297
F	FLC501
F	HOH620
F	HOH924
F	HOH1002
F	HOH1114
F	HOH1199
F	HOH1262

site_id	CC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE FLC F 501

Chain	Residue
E	5AD401
F	PHE158
F	ALA159
F	ARG161
F	ARG206
F	TYR215
F	PHE223
F	ARG230
F	B12301
F	HOH590
F	HOH1109

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DHL F 601

Chain	Residue
F	PRO152
F	CYS182

site_id	CC6
Number of Residues	33
Details	BINDING SITE FOR RESIDUE B12 G 301

Chain	Residue
G	LEU34
G	LEU35
G	PRO36
G	ASP104
G	PRO113
G	ILE115
G	ALA117
G	GLN118
G	THR119
G	HIS122
G	TYR129
G	GLN131
G	ARG144
G	SER146
G	CYS149
G	ILE160
G	PHE196
G	TRP200
G	5AD283
G	HOH285
G	HOH287
G	HOH290
G	HOH303
G	HOH306
G	HOH311
G	HOH344
G	HOH494
G	FLC501
G	HOH658
G	HOH893
G	HOH1330
G	HOH2051
H	5AD401

site_id	CC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE FLC G 501

Chain	Residue
G	PHE158
G	ARG161
G	ARG206
G	TYR215
G	PHE223
G	ARG230
G	HOH295
G	B12301
G	HOH475
G	HOH937
H	5AD401

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DHL G 601

Chain	Residue
G	PRO152
G	HIS180
G	CYS182

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 5AD G 401

Chain	Residue
G	PRO109
G	ASN110
G	ARG111
H	B12301
H	FLC501

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 5AD G 283

Chain	Residue
G	TRP30
G	GLU33
G	HIS122
G	VAL123
G	PRO176
G	B12301

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 5AD H 401

Chain	Residue
G	HOH298
G	B12301
G	FLC501
H	PRO109
H	ASN110
H	ARG111

site_id	DC3
Number of Residues	34
Details	BINDING SITE FOR RESIDUE B12 H 301

Chain	Residue
G	ARG111
G	5AD401
H	LEU34
H	LEU35
H	PRO36
H	ASP104
H	PRO113
H	ILE115
H	ALA117
H	GLN118
H	THR119
H	HIS122
H	TYR129
H	GLN131
H	ARG144
H	SER146
H	CYS149
H	ILE160
H	PHE196
H	TRP200
H	HOH283
H	HOH284
H	HOH288
H	HOH293
H	HOH295
H	HOH298
H	HOH304
H	HOH497
H	FLC501
H	HOH627
H	HOH948
H	HOH1096
H	HOH2010
H	HOH2076

site_id	DC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC H 501

Chain	Residue
G	5AD401
H	PHE158
H	ARG161
H	ARG206
H	TYR215
H	PHE223
H	ARG230
H	B12301
H	HOH325
H	HOH528

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DHL H 601

Chain	Residue
G	PRO184
G	THR185
G	HOH1020
H	PRO152
H	CYS182

site_id	DC6
Number of Residues	34
Details	BINDING SITE FOR RESIDUE B12 I 301

Chain	Residue
I	LEU34
I	LEU35
I	PRO36
I	ASP104
I	PRO113
I	ILE115
I	ALA117
I	GLN118
I	THR119
I	HIS122
I	TYR129
I	GLN131
I	ARG144
I	SER146
I	CYS149
I	ILE160
I	PHE196
I	TRP200
I	HOH285
I	HOH286
I	HOH290
I	HOH299
I	HOH300
I	HOH326
I	FLC501
I	HOH529
I	HOH875
I	HOH995
I	HOH1024
I	HOH1030
I	HOH1121
I	HOH2063
J	ARG111
J	5AD401

site_id	DC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE FLC I 501

Chain	Residue
I	PHE158
I	ARG161
I	ARG206
I	TYR215
I	PHE223
I	ARG230
I	HOH296
I	B12301
I	HOH302
I	HOH790
J	5AD401

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DHL I 601

Chain	Residue
I	PRO152
I	CYS182
J	ASP188
J	HOH385

site_id	DC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 5AD I 401

Chain	Residue
I	PRO109
I	ASN110
I	ARG111
I	HOH900
J	HOH288
J	B12301
J	FLC501

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 5AD I 283

Chain	Residue
I	TRP30
I	GLU33
I	HIS122
I	VAL123
I	TYR128

site_id	EC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 5AD J 401

Chain	Residue
I	B12301
I	FLC501
I	HOH652
J	PRO109
J	ASN110
J	ARG111

site_id	EC3
Number of Residues	32
Details	BINDING SITE FOR RESIDUE B12 J 301

Chain	Residue
I	ARG111
I	5AD401
J	LEU34
J	LEU35
J	PRO36
J	ASP104
J	PRO113
J	ILE115
J	ALA117
J	GLN118
J	THR119
J	HIS122
J	TYR129
J	GLN131
J	ARG144
J	SER146
J	CYS149
J	ILE160
J	PHE196
J	TRP200
J	HOH283
J	HOH285
J	HOH289
J	HOH294
J	HOH297
J	HOH438
J	HOH460
J	FLC501
J	HOH545
J	HOH612
J	HOH1056
J	HOH1669

site_id	EC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE FLC J 501

Chain	Residue
I	5AD401
J	PHE158
J	ARG161
J	ARG206
J	TYR215
J	PHE223
J	ARG230
J	HOH293
J	B12301
J	HOH360
J	HOH690

site_id	EC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DHL J 601

Chain	Residue
J	PRO152
J	CYS182

site_id	EC6
Number of Residues	30
Details	BINDING SITE FOR RESIDUE B12 K 301

Chain	Residue
K	LEU34
K	LEU35
K	PRO36
K	ASP104
K	PRO113
K	ILE115
K	ALA117
K	GLN118
K	THR119
K	HIS122
K	TYR129
K	GLN131
K	ARG144
K	SER146
K	CYS149
K	ILE160
K	PHE196
K	TRP200
K	HOH285
K	HOH288
K	HOH289
K	HOH294
K	HOH297
K	HOH459
K	FLC501
K	HOH794
K	HOH797
K	HOH1542
L	ARG111
L	5AD401

site_id	EC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC K 501

Chain	Residue
K	PHE158
K	ARG161
K	ARG206
K	TYR215
K	PHE223
K	ARG230
K	HOH290
K	B12301
K	HOH1306
L	5AD401

site_id	EC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DHL K 601

Chain	Residue
K	PRO152
K	CYS182
L	PRO184
L	HOH328

site_id	EC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 5AD K 401

Chain	Residue
K	PRO109
K	ASN110
K	ARG111
K	HOH1049
K	HOH1335
L	HOH287
L	B12301
L	FLC501

site_id	FC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 5AD L 401

Chain	Residue
K	B12301
K	HOH472
K	FLC501
L	PRO109
L	ASN110
L	ARG111

site_id	FC2
Number of Residues	33
Details	BINDING SITE FOR RESIDUE B12 L 301

Chain	Residue
K	ARG111
K	5AD401
L	LEU34
L	LEU35
L	PRO36
L	ASP104
L	PRO113
L	ILE115
L	ALA117
L	GLN118
L	THR119
L	HIS122
L	TYR129
L	GLN131
L	ARG144
L	SER146
L	CYS149
L	ILE160
L	PHE196
L	TRP200
L	HOH284
L	HOH289
L	HOH290
L	HOH300
L	HOH376
L	FLC501
L	HOH522
L	HOH940
L	HOH983
L	HOH1077
L	HOH1202
L	HOH1273
L	HOH2053

site_id	FC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE FLC L 501

Chain	Residue
K	5AD401
L	PHE158
L	ARG161
L	ARG206
L	TYR215
L	PHE223
L	ARG230
L	HOH286
L	HOH296
L	B12301
L	HOH743
L	HOH825

site_id	FC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DHL L 601

Chain	Residue
L	PRO152
L	CYS182

site_id	FC5
Number of Residues	30
Details	BINDING SITE FOR RESIDUE B12 M 301

Chain	Residue
M	LEU34
M	LEU35
M	PRO36
M	ASP104
M	PRO113
M	ILE115
M	ALA117
M	GLN118
M	THR119
M	HIS122
M	TYR129
M	GLN131
M	ARG144
M	SER146
M	CYS149
M	ILE160
M	PHE196
M	TRP200
M	TYR205
M	HOH284
M	HOH285
M	HOH286
M	HOH287
M	HOH295
M	HOH471
M	FLC501
M	HOH514
M	HOH2055
N	ARG111
N	5AD401

site_id	FC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE FLC M 501

Chain	Residue
M	PHE158
M	ARG161
M	ARG206
M	TYR215
M	PHE223
M	ARG230
M	B12301
M	HOH1282
M	HOH1342
M	HOH2025
N	5AD401

site_id	FC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DHL M 601

Chain	Residue
M	PRO152
M	CYS182

site_id	FC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 5AD M 401

Chain	Residue
M	PRO109
M	ASN110
M	ARG111
N	HOH294
N	B12301
N	FLC501

site_id	FC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 5AD N 401

Chain	Residue
M	HOH300
M	B12301
M	FLC501
N	PRO109
N	ASN110
N	ARG111
N	HOH890

site_id	GC1
Number of Residues	32
Details	BINDING SITE FOR RESIDUE B12 N 301

Chain	Residue
M	ARG111
M	5AD401
N	LEU34
N	LEU35
N	PRO36
N	ASP104
N	PRO113
N	ILE115
N	ALA117
N	GLN118
N	THR119
N	HIS122
N	TYR129
N	GLN131
N	ARG144
N	SER146
N	CYS149
N	ILE160
N	PHE196
N	TRP200
N	HOH286
N	HOH288
N	HOH290
N	HOH297
N	HOH299
N	HOH411
N	HOH417
N	FLC501
N	HOH725
N	HOH795
N	HOH1071
N	HOH2040

site_id	GC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE FLC N 501

Chain	Residue
M	5AD401
N	PHE158
N	ARG161
N	ARG206
N	TYR215
N	PHE223
N	ARG230
N	B12301
N	HOH440
N	HOH984
N	HOH1326

site_id	GC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DHL N 601

Chain	Residue
M	PRO184
M	HOH324
M	HOH1381
N	PRO152
N	CYS182

site_id	GC4
Number of Residues	32
Details	BINDING SITE FOR RESIDUE B12 O 301

Chain	Residue
O	LEU34
O	LEU35
O	PRO36
O	ASP104
O	PRO113
O	ILE115
O	ALA117
O	GLN118
O	THR119
O	HIS122
O	TYR129
O	GLN131
O	ARG144
O	SER146
O	CYS149
O	ILE160
O	PHE196
O	TRP200
O	HOH287
O	HOH290
O	HOH293
O	HOH296
O	HOH297
O	HOH299
O	HOH303
O	HOH391
O	FLC501
O	HOH811
O	HOH1026
O	HOH1088
O	HOH1229
P	5AD401

site_id	GC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC O 501

Chain	Residue
O	PHE158
O	ARG161
O	ARG206
O	TYR215
O	PHE223
O	ARG230
O	B12301
O	HOH462
O	HOH2042
P	5AD401

site_id	GC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DHL O 601

Chain	Residue
O	PRO152
O	HIS180
O	CYS182

site_id	GC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 5AD O 401

Chain	Residue
O	PRO109
O	ASN110
O	ARG111
O	HOH1586
P	B12301
P	FLC501
P	HOH2023

site_id	GC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 5AD P 401

Chain	Residue
O	B12301
O	FLC501
P	PRO109
P	ASN110
P	ARG111
P	HOH1057

site_id	GC9
Number of Residues	33
Details	BINDING SITE FOR RESIDUE B12 P 301

Chain	Residue
O	ARG111
O	5AD401
P	LEU34
P	LEU35
P	PRO36
P	ASP104
P	PRO113
P	ILE115
P	ALA117
P	GLN118
P	THR119
P	HIS122
P	TYR129
P	GLN131
P	ARG144
P	SER146
P	CYS149
P	ILE160
P	PHE196
P	TRP200
P	HOH286
P	HOH287
P	HOH292
P	HOH347
P	HOH355
P	HOH463
P	FLC501
P	HOH527
P	HOH626
P	HOH977
P	HOH1329
P	HOH2031
P	HOH2057

site_id	HC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC P 501

Chain	Residue
O	5AD401
P	PHE158
P	ARG161
P	ARG206
P	TYR215
P	PHE223
P	ARG230
P	B12301
P	HOH322
P	HOH369

site_id	HC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DHL P 601

Chain	Residue
O	PRO184
O	HOH818
P	PRO152
P	CYS182

site_id	HC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO P 283

Chain	Residue
P	THR185
P	ARG186
P	ALA187

site_id	HC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO P 284

Chain	Residue
P	ARG91
P	LEU94
P	LEU97
P	GLN98
P	ILE99

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	128
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21697092","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22642810","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SOM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)