3SL4

Crystal structure of the catalytic domain of PDE4D2 with compound 10D

Summary for 3SL4

• Entry DOI: 10.2210/pdb3sl4/pdb
• Related: 1PTW 3SL3 3SL5 3SL6 3SL8
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, 1,2-ETHANEDIOL, ... (9 entities in total)
• Functional Keywords: catalytic mechanism, camp hydrolysis, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Apical cell membrane : Q08499
• Total number of polymer chains: 4
• Total formula weight: 173442.34

Authors

Feil, S.F. (deposition date: 2011-06-24, release date: 2011-10-26, Last modification date: 2024-02-28)

• Primary citation: Nankervis, J.L.,Feil, S.C.,Hancock, N.C.,Zheng, Z.,Ng, H.L.,Morton, C.J.,Holien, J.K.,Ho, P.W.,Frazzetto, M.M.,Jennings, I.G.,Manallack, D.T.,Martin, T.J.,Thompson, P.E.,Parker, M.W.; Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2.; Bioorg.Med.Chem.Lett., 21:7089-7093, 2011; PubMed: 22030030; DOI: 10.1016/j.bmcl.2011.09.109

Experimental method

X-RAY DIFFRACTION (1.9 Å)