3SL4
Crystal structure of the catalytic domain of PDE4D2 with compound 10D
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| C | 0007165 | biological_process | signal transduction |
| C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| D | 0007165 | biological_process | signal transduction |
| D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 1 |
| Chain | Residue |
| A | PO420 |
| A | HIS164 |
| A | HIS200 |
| A | ASP201 |
| A | ASP318 |
| A | HOH486 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 2 |
| Chain | Residue |
| A | HOH486 |
| A | HOH490 |
| A | HOH529 |
| A | PO420 |
| A | HOH54 |
| A | ASP201 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 4 |
| Chain | Residue |
| A | LYS262 |
| A | ILE265 |
| A | ASP266 |
| B | HOH500 |
| B | HOH535 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 5 |
| Chain | Residue |
| A | GLU218 |
| C | LYS239 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS A 6 |
| Chain | Residue |
| A | PRO138 |
| A | ASP140 |
| A | THR141 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 7 |
| Chain | Residue |
| A | ARG350 |
| C | EDO8 |
| C | THR148 |
| C | ASP151 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 9 |
| Chain | Residue |
| A | ASP156 |
| A | ALA158 |
| A | PRO205 |
| A | GLU339 |
| A | ARG342 |
| A | ARG346 |
| A | HOH482 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 10 |
| Chain | Residue |
| A | LEU175 |
| A | THR178 |
| A | TRP384 |
| A | VAL388 |
| A | ILE395 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 11 |
| Chain | Residue |
| A | LEU132 |
| A | LYS136 |
| A | ILE137 |
| A | VAL139 |
| A | HOH471 |
| A | HOH478 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG A 440 |
| Chain | Residue |
| A | ASN115 |
| A | ARG116 |
| A | GLU150 |
| A | ASP151 |
| A | TYR153 |
| A | ASN162 |
| A | HOH542 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 13 |
| Chain | Residue |
| A | EDO18 |
| A | LEU188 |
| A | LYS255 |
| A | GLN256 |
| A | SER259 |
| D | DMS8 |
| D | GLU182 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 14 |
| Chain | Residue |
| A | PHE238 |
| A | PHE249 |
| A | ARG257 |
| A | ARG261 |
| A | HOH536 |
| A | HOH539 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 15 |
| Chain | Residue |
| A | ASP266 |
| A | GLN311 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 16 |
| Chain | Residue |
| A | GLU218 |
| C | HIS152 |
| C | LYS239 |
| C | HOH479 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 17 |
| Chain | Residue |
| A | ASN115 |
| A | ALA155 |
| A | ASN162 |
| A | ILE163 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 18 |
| Chain | Residue |
| A | EDO13 |
| A | THR186 |
| A | LEU188 |
| A | SER259 |
| A | MET263 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 19 |
| Chain | Residue |
| A | ARG330 |
| A | GLU366 |
| A | THR409 |
| A | HOH463 |
| B | PRO411 |
| B | GLN412 |
| site_id | BC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 A 20 |
| Chain | Residue |
| A | ZN1 |
| A | ZN2 |
| A | JN423 |
| A | HIS160 |
| A | HIS164 |
| A | ASP201 |
| A | ASP318 |
| A | HOH452 |
| A | HOH485 |
| A | HOH486 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 21 |
| Chain | Residue |
| D | LYS239 |
| D | GLN242 |
| A | LYS239 |
| A | GLN242 |
| A | HOH547 |
| C | ASN216 |
| site_id | CC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE JN4 A 23 |
| Chain | Residue |
| A | PO420 |
| A | TYR159 |
| A | LEU319 |
| A | ASN321 |
| A | PRO322 |
| A | TYR329 |
| A | THR333 |
| A | ILE336 |
| A | MET337 |
| A | MET357 |
| A | GLN369 |
| A | PHE372 |
| A | HOH444 |
| A | HOH485 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 441 |
| Chain | Residue |
| A | GLN258 |
| B | EDO9 |
| B | GLN210 |
| B | ASN214 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 442 |
| Chain | Residue |
| A | HIS105 |
| A | VAL106 |
| A | PHE107 |
| A | ARG108 |
| A | GLN331 |
| site_id | CC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 443 |
| Chain | Residue |
| A | THR148 |
| A | HIS152 |
| A | GLU243 |
| A | HOH462 |
| C | HOH73 |
| C | PHE211 |
| C | THR215 |
| C | ARG350 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 1 |
| Chain | Residue |
| B | PO420 |
| B | HIS164 |
| B | HIS200 |
| B | ASP201 |
| B | ASP318 |
| B | HOH489 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 2 |
| Chain | Residue |
| B | PO420 |
| B | HOH47 |
| B | HOH57 |
| B | ASP201 |
| B | HOH484 |
| B | HOH489 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 4 |
| Chain | Residue |
| B | SER208 |
| B | PHE340 |
| B | PRO356 |
| B | CYS358 |
| B | HOH482 |
| site_id | CC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EPE B 6 |
| Chain | Residue |
| B | EDO18 |
| B | ASP140 |
| B | LYS290 |
| B | VAL292 |
| C | THR253 |
| C | LYS254 |
| C | HOH485 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 7 |
| Chain | Residue |
| B | EDO13 |
| B | GLU150 |
| B | ASP151 |
| B | TYR153 |
| B | ASN162 |
| site_id | DC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B 8 |
| Chain | Residue |
| B | GLU218 |
| site_id | DC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 9 |
| Chain | Residue |
| A | GLN258 |
| A | EDO441 |
| B | ASN214 |
| B | HOH515 |
| D | SER294 |
| D | SER295 |
| site_id | DC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 10 |
| Chain | Residue |
| B | HOH71 |
| B | GLU218 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 11 |
| Chain | Residue |
| B | HOH58 |
| B | GLN210 |
| B | HOH454 |
| B | HOH509 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 13 |
| Chain | Residue |
| B | DMS7 |
| B | ASN115 |
| B | ALA155 |
| B | ASN162 |
| B | ILE163 |
| B | ARG335 |
| site_id | DC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 15 |
| Chain | Residue |
| B | PHE211 |
| B | ASN214 |
| B | GLU347 |
| B | MET352 |
| B | GLU353 |
| B | SER355 |
| site_id | DC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 16 |
| Chain | Residue |
| B | LEU176 |
| B | SER177 |
| B | THR178 |
| B | LEU181 |
| B | GLU182 |
| B | HOH459 |
| B | HOH486 |
| site_id | DC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 17 |
| Chain | Residue |
| B | ALA183 |
| B | PHE185 |
| site_id | EC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 18 |
| Chain | Residue |
| B | EPE6 |
| B | EDO19 |
| B | LYS290 |
| B | LEU387 |
| B | VAL388 |
| B | HIS389 |
| B | HOH527 |
| C | HOH485 |
| site_id | EC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 19 |
| Chain | Residue |
| B | EDO18 |
| B | PRO179 |
| B | ALA180 |
| B | HIS389 |
| B | PRO390 |
| B | ASP391 |
| C | EDO6 |
| C | THR253 |
| C | LYS255 |
| site_id | EC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 B 20 |
| Chain | Residue |
| B | ZN1 |
| B | ZN2 |
| B | JN421 |
| B | HIS160 |
| B | HIS164 |
| B | ASP201 |
| B | ASP318 |
| B | HOH451 |
| B | HOH489 |
| B | HOH510 |
| site_id | EC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE JN4 B 21 |
| Chain | Residue |
| B | PO420 |
| B | TYR159 |
| B | MET273 |
| B | LEU319 |
| B | ASN321 |
| B | TRP332 |
| B | THR333 |
| B | ILE336 |
| B | MET337 |
| B | MET357 |
| B | GLN369 |
| B | PHE372 |
| B | HOH510 |
| B | HOH526 |
| site_id | EC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 8 |
| Chain | Residue |
| A | EDO7 |
| C | HIS152 |
| C | GLU243 |
| site_id | EC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN C 1 |
| Chain | Residue |
| C | PO417 |
| C | HIS164 |
| C | HIS200 |
| C | ASP201 |
| C | ASP318 |
| C | HOH487 |
| site_id | EC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN C 2 |
| Chain | Residue |
| C | PO417 |
| C | ASP201 |
| C | HOH481 |
| C | HOH487 |
| C | HOH491 |
| C | HOH516 |
| site_id | EC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 4 |
| Chain | Residue |
| C | ASN115 |
| C | ALA155 |
| C | ASN161 |
| C | ASN162 |
| C | ILE163 |
| site_id | EC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO C 5 |
| Chain | Residue |
| B | HIS389 |
| B | PRO390 |
| C | THR134 |
| C | PHE135 |
| C | LYS136 |
| C | ASN251 |
| C | GLN256 |
| site_id | FC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 6 |
| Chain | Residue |
| B | EDO19 |
| C | LEU188 |
| C | LYS255 |
| C | SER259 |
| site_id | FC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EPE C 7 |
| Chain | Residue |
| C | HIS105 |
| C | VAL106 |
| C | PHE107 |
| C | ARG108 |
| C | GLU111 |
| C | GLN327 |
| C | LEU328 |
| C | GLN331 |
| site_id | FC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 440 |
| Chain | Residue |
| C | LEU175 |
| C | THR178 |
| C | TRP384 |
| C | ASP391 |
| site_id | FC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS C 10 |
| Chain | Residue |
| C | ARG257 |
| C | ARG261 |
| C | HOH489 |
| site_id | FC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 11 |
| Chain | Residue |
| C | LYS262 |
| C | ASP266 |
| D | ASN224 |
| D | ASP225 |
| site_id | FC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 12 |
| Chain | Residue |
| C | ASP266 |
| C | ALA270 |
| C | LYS275 |
| C | GLN311 |
| site_id | FC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 13 |
| Chain | Residue |
| C | ASP156 |
| C | VAL157 |
| C | ALA158 |
| C | GLU339 |
| C | ARG342 |
| C | HOH507 |
| site_id | FC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 14 |
| Chain | Residue |
| A | ASP156 |
| C | GLU150 |
| C | ASP151 |
| C | TYR153 |
| site_id | FC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 15 |
| Chain | Residue |
| C | HIS154 |
| C | ASP203 |
| C | PRO205 |
| C | LEU219 |
| site_id | GC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 C 17 |
| Chain | Residue |
| C | ZN1 |
| C | ZN2 |
| C | JN418 |
| C | HIS160 |
| C | HIS164 |
| C | ASP201 |
| C | ASP318 |
| C | HOH484 |
| C | HOH487 |
| C | HOH503 |
| site_id | GC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE JN4 C 18 |
| Chain | Residue |
| C | PO417 |
| C | TYR159 |
| C | MET273 |
| C | LEU319 |
| C | ASN321 |
| C | PRO322 |
| C | THR333 |
| C | ILE336 |
| C | MET337 |
| C | MET357 |
| C | GLN369 |
| C | PHE372 |
| C | HOH482 |
| C | HOH484 |
| site_id | GC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO D 5 |
| Chain | Residue |
| B | THR215 |
| B | ARG350 |
| B | HOH528 |
| D | THR148 |
| D | HIS152 |
| D | GLU243 |
| D | HOH495 |
| site_id | GC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG D 12 |
| Chain | Residue |
| D | EDO7 |
| D | ASN100 |
| D | LYS101 |
| D | TRP102 |
| D | VAL174 |
| D | HOH447 |
| D | HOH534 |
| site_id | GC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN D 1 |
| Chain | Residue |
| D | PO424 |
| D | HIS164 |
| D | HIS200 |
| D | ASP201 |
| D | ASP318 |
| D | HOH482 |
| site_id | GC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN D 2 |
| Chain | Residue |
| D | PO424 |
| D | HOH76 |
| D | ASP201 |
| D | HOH482 |
| D | HOH546 |
| D | HOH557 |
| site_id | GC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 4 |
| Chain | Residue |
| A | THR134 |
| A | ASN251 |
| A | GLN256 |
| A | HOH460 |
| D | PRO179 |
| D | ASP391 |
| site_id | GC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 440 |
| Chain | Residue |
| D | LEU181 |
| D | ALA183 |
| D | VAL184 |
| D | PHE185 |
| D | HOH449 |
| site_id | GC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO D 6 |
| Chain | Residue |
| D | ASN115 |
| site_id | HC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 7 |
| Chain | Residue |
| D | PEG12 |
| D | LEU175 |
| D | THR178 |
| D | ASP391 |
| D | HOH473 |
| site_id | HC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS D 8 |
| Chain | Residue |
| A | EDO13 |
| A | HOH477 |
| D | SER177 |
| D | THR178 |
| D | PRO179 |
| D | GLU182 |
| site_id | HC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS D 9 |
| Chain | Residue |
| B | GLU349 |
| B | ARG350 |
| D | ASP140 |
| D | THR144 |
| site_id | HC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO D 10 |
| Chain | Residue |
| D | HIS123 |
| site_id | HC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 11 |
| Chain | Residue |
| D | EDO14 |
| D | ASP266 |
| D | GLN311 |
| site_id | HC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG D 441 |
| Chain | Residue |
| C | ASP225 |
| C | HOH464 |
| D | GLN258 |
| D | LYS262 |
| D | ASP266 |
| site_id | HC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS D 13 |
| Chain | Residue |
| D | EDO17 |
| D | ASN115 |
| D | GLU150 |
| D | ASP151 |
| D | TYR153 |
| D | ASN162 |
| site_id | HC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 14 |
| Chain | Residue |
| D | EDO11 |
| D | ASP266 |
| D | LYS275 |
| D | GLN311 |
| site_id | HC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 15 |
| Chain | Residue |
| D | MET286 |
| D | THR289 |
| D | LYS291 |
| D | LEU299 |
| site_id | IC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG D 16 |
| Chain | Residue |
| D | PRO325 |
| D | LEU326 |
| D | ASP401 |
| D | ASN402 |
| site_id | IC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 17 |
| Chain | Residue |
| D | DMS13 |
| D | ASN115 |
| D | ALA155 |
| D | ASN161 |
| D | ASN162 |
| site_id | IC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 18 |
| Chain | Residue |
| D | ASN100 |
| D | GLU128 |
| D | HIS173 |
| D | SER177 |
| D | HOH472 |
| site_id | IC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG D 19 |
| Chain | Residue |
| D | ASP156 |
| D | VAL157 |
| D | ALA158 |
| D | PRO205 |
| D | GLU339 |
| D | ARG346 |
| D | HOH476 |
| site_id | IC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO D 20 |
| Chain | Residue |
| C | ASN231 |
| C | LEU234 |
| C | PHE238 |
| C | ARG261 |
| D | LEU221 |
| D | ASN224 |
| D | HOH488 |
| site_id | IC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO D 21 |
| Chain | Residue |
| C | ASN231 |
| D | EDO22 |
| D | MET222 |
| D | TYR223 |
| D | ASN224 |
| D | SER226 |
| D | ASN231 |
| D | HOH452 |
| D | HOH468 |
| site_id | IC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 22 |
| Chain | Residue |
| D | EDO21 |
| D | SER226 |
| D | ASN231 |
| D | HOH468 |
| site_id | IC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS D 23 |
| Chain | Residue |
| D | HIS105 |
| D | VAL106 |
| D | PHE107 |
| D | ARG108 |
| D | GLN327 |
| D | LEU328 |
| D | GLN331 |
| site_id | IC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 D 24 |
| Chain | Residue |
| D | ZN1 |
| D | ZN2 |
| D | HIS160 |
| D | HIS164 |
| D | ASP201 |
| D | ASP318 |
| D | JN4442 |
| D | HOH482 |
| D | HOH483 |
| D | HOH518 |
| site_id | JC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE JN4 D 442 |
| Chain | Residue |
| D | PO424 |
| D | TYR159 |
| D | MET273 |
| D | LEU319 |
| D | ASN321 |
| D | PRO322 |
| D | TYR329 |
| D | THR333 |
| D | ILE336 |
| D | MET337 |
| D | MET357 |
| D | SER368 |
| D | GLN369 |
| D | PHE372 |
| D | HOH483 |
| D | HOH554 |
| D | HOH559 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS200-PHE211 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q07343 |
| Chain | Residue | Details |
| A | HIS160 | |
| B | HIS160 | |
| C | HIS160 | |
| D | HIS160 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 |
| Chain | Residue | Details |
| A | HIS160 | |
| D | HIS160 | |
| D | ASN321 | |
| D | GLN369 | |
| A | ASN321 | |
| A | GLN369 | |
| B | HIS160 | |
| B | ASN321 | |
| B | GLN369 | |
| C | HIS160 | |
| C | ASN321 | |
| C | GLN369 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS164 | |
| B | HIS164 | |
| C | HIS164 | |
| D | HIS164 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS200 | |
| A | ASP318 | |
| B | HIS200 | |
| B | ASP318 | |
| C | HIS200 | |
| C | ASP318 | |
| D | HIS200 | |
| D | ASP318 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW |
| Chain | Residue | Details |
| A | ASP201 | |
| A | PHE372 | |
| B | ASP201 | |
| B | PHE372 | |
| C | ASP201 | |
| C | PHE372 | |
| D | ASP201 | |
| D | PHE372 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) |
| Chain | Residue | Details |
| A | LYS85 | |
| B | LYS85 | |
| C | LYS85 | |
| D | LYS85 |
