3SDI

Structure of yeast 20S open-gate proteasome with Compound 20

Summary for 3SDI

Related3MG4 3MG6 3MG7 3MG8 3OEU 3OEV 3SDK
Related PRD IDPRD_001071
DescriptorProteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ... (18 entities in total)
Functional Keywords20s proteasome, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains28
Total molecular weight707777.99
Authors
Sintchak, M.D. (deposition date: 2011-06-09, release date: 2012-06-13, Last modification date: 2017-11-08)
Primary citation
Blackburn, C.,Barrett, C.,Blank, J.L.,Bruzzese, F.J.,Bump, N.,Dick, L.R.,Fleming, P.,Garcia, K.,Hales, P.,Hu, Z.,Jones, M.,Liu, J.X.,Sappal, D.S.,Sintchak, M.D.,Tsu, C.,Gigstad, K.M.
Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
Bioorg.Med.Chem.Lett., 20:6581-6586, 2010
PubMed: 20875739 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2010.09.032
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.65 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24670.5%6.8%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution