3OEV
Structure of yeast 20S open-gate proteasome with Compound 25
Summary for 3OEV
Entry DOI | 10.2210/pdb3oev/pdb |
Related PRD ID | PRD_000959 |
Descriptor | Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (17 entities in total) |
Functional Keywords | 20s proteasome, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (Baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 707767.21 |
Authors | Sintchak, M.D. (deposition date: 2010-08-13, release date: 2011-07-20, Last modification date: 2024-02-21) |
Primary citation | Blackburn, C.,Barrett, C.,Blank, J.L.,Bruzzese, F.J.,Bump, N.,Dick, L.R.,Fleming, P.,Garcia, K.,Hales, P.,Hu, Z.,Jones, M.,Liu, J.X.,Sappal, D.S.,Sintchak, M.D.,Tsu, C.,Gigstad, K.M. Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome. Bioorg.Med.Chem.Lett., 20:6581-6586, 2010 Cited by PubMed: 20875739DOI: 10.1016/j.bmcl.2010.09.032 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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