3SA9
Crystal structure of Wild-type HIV-1 protease in complex With AF68
Summary for 3SA9
Entry DOI | 10.2210/pdb3sa9/pdb |
Related | 3SA3 3SA4 3SA5 3SA6 3SA7 3SA8 3SAA 3SAB 3SAC |
Related PRD ID | PRD_000952 |
Descriptor | Protease, N~2~-acetyl-N-[(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]-L-isoleucinamide, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | hiv-1 protease, drug resistance, drug design, protease inhibitors, aids, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22347.33 |
Authors | Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2011-06-02, release date: 2012-06-06, Last modification date: 2023-09-13) |
Primary citation | Altman, M.D.,Nalam, M.N.L.,Ali, A.,Cao, H.,Rana, T.M.,Schiffer, C.A.,Tidor, B. Protease Inhibitors that protrude out from substrate envelope are more susceptible to developing drug resistance To be Published, |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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