Crystal Structure of D48V mutant of Human Glycolipid Transfer Protein complexed with 3-O-sulfo galactosylceramide containing nervonoyl acyl chain

Summary for 3S0I

Related2EVT 3RZN 3RIC 3RWV 3S0K 1SWX
DescriptorGlycolipid transfer protein, (15Z)-N-((1S,2R,3E)-2-HYDROXY-1-{[(3-O-SULFO-BETA-D-GALACTOPYRANOSYL)OXY]METHYL}HEPTADEC-3-ENYL)TETRACOS-15-ENAMIDE (3 entities in total)
Functional Keywordsgltp-fold, transport, lipid transport
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q9NZD2
Total number of polymer chains1
Total molecular weight24752.12
Samygina, V.,Popov, A.N.,Cabo-Bilbao, A.,Ochoa-Lizarralde, B.,Patel, D.J.,Brown, R.E.,Malinina, L. (deposition date: 2011-05-13, release date: 2012-02-08)
Primary citation
Samygina, V.R.,Popov, A.N.,Cabo-Bilbao, A.,Ochoa-Lizarralde, B.,Goni-de-Cerio, F.,Zhai, X.,Molotkovsky, J.G.,Patel, D.J.,Brown, R.E.,Malinina, L.
Enhanced selectivity for sulfatide by engineered human glycolipid transfer protein.
Structure, 19:1644-1654, 2011
PubMed: 22078563 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2011.09.011
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20380.5%2.3%9.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-08-05