3RLY

Human Thrombin in complex with MI329

3RLY の概要

• エントリーDOI: 10.2210/pdb3rly/pdb
• 関連するPDBエントリー: 1K1O 2ZQ1 3F68 3P17 3QTO 3RLW 3RM0 3RM2 3RML 3RMM 3RMN 3RMO
• 関連するBIRD辞書のPRD_ID: PRD_001100
• 分子名称: Thrombin Light Chain, Thrombin Heavy Chain, Hirudin variant-2, ... (9 entities in total)
• 機能のキーワード: serine protease, kringle, hydrolase, blood coagulation, blood clotting, convertion of fibrinogen to fibrin, cleavage on pairs of basic residues, hirudin, glycosylation, blood, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 36936.83

構造登録者

Biela, A.,Heine, A.,Klebe, G. (登録日: 2011-04-20, 公開日: 2012-04-25, 最終更新日: 2023-12-06)

• 主引用文献: Biela, A.,Sielaff, F.,Terwesten, F.,Heine, A.,Steinmetzer, T.,Klebe, G.; Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect; J.Med.Chem., 55:6094-6110, 2012; PubMed: 22612268; DOI: 10.1021/jm300337q

実験手法

X-RAY DIFFRACTION (1.51 Å)