3QWQ

Crystal structure of the extracellular domain of the epidermal growth factor receptor in complex with an adnectin

3QWQ の概要

• エントリーDOI: 10.2210/pdb3qwq/pdb
• 関連するPDBエントリー: 3QWR
• 分子名称: Epidermal growth factor receptor, ADNECTIN, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: cell surface receptor, tyrosine kinase, glycoprotein, adnectin, antitumor, drug, engineered binding protein, antibody mimic, signaling protein, protein binding-signaling protein complex, protein binding/signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87637.55

構造登録者

Sheriff, S. (登録日: 2011-02-28, 公開日: 2012-02-01, 最終更新日: 2023-09-13)

• 主引用文献: Ramamurthy, V.,Krystek, S.R.,Bush, A.,Wei, A.,Emanuel, S.L.,Das Gupta, R.,Janjua, A.,Cheng, L.,Murdock, M.,Abramczyk, B.,Cohen, D.,Lin, Z.,Morin, P.,Davis, J.H.,Dabritz, M.,McLaughlin, D.C.,Russo, K.A.,Chao, G.,Wright, M.C.,Jenny, V.A.,Engle, L.J.,Furfine, E.,Sheriff, S.; Structures of adnectin/protein complexes reveal an expanded binding footprint.; Structure, 20:259-269, 2012; PubMed: 22325775; DOI: 10.1016/j.str.2011.11.016

実験手法

X-RAY DIFFRACTION (2.75 Å)