3QI2
A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco
Summary for 3QI2
Entry DOI | 10.2210/pdb3qi2/pdb |
Related | 1kjy 1Y3A 2OM2 3QE0 |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | rgs14 goloco, ras-like domain, all-helical domain, goloco motif, arginine finger, signaling protein, lipoprotein, transducer, guanine nucleotide dissociation inhibitor, gtp binding, nucleotide binding, adp-ribosylation |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (By similarity): P63096 O43566 |
Total number of polymer chains | 4 |
Total formula weight | 84421.36 |
Authors | Bosch, D.E.,Willard, F.S.,Kimple, A.J.,Miley, M.J.,Siderovski, D.P. (deposition date: 2011-01-26, release date: 2012-02-01, Last modification date: 2023-09-13) |
Primary citation | Bosch, D.E.,Willard, F.S.,Ramanujam, R.,Kimple, A.J.,Willard, M.D.,Naqvi, N.I.,Siderovski, D.P. A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis Plos Pathog., 8:e1002553-e1002553, 2012 Cited by PubMed: 22383884DOI: 10.1371/journal.ppat.1002553 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.797 Å) |
Structure validation
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