3QI2

A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco

Summary for 3QI2

Entry DOI	10.2210/pdb3qi2/pdb
Related	1Y3A 1kjy 2OM2 3QE0
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywords	rgs14 goloco, ras-like domain, all-helical domain, goloco motif, arginine finger, signaling protein, lipoprotein, transducer, guanine nucleotide dissociation inhibitor, gtp binding, nucleotide binding, adp-ribosylation
Biological source	Homo sapiens (human) More
Cellular location	Nucleus (By similarity): P63096 O43566
Total number of polymer chains	4
Total formula weight	84421.36
Authors	Bosch, D.E.,Willard, F.S.,Kimple, A.J.,Miley, M.J.,Siderovski, D.P. (deposition date: 2011-01-26, release date: 2012-02-01, Last modification date: 2023-09-13)
Primary citation	Bosch, D.E.,Willard, F.S.,Ramanujam, R.,Kimple, A.J.,Willard, M.D.,Naqvi, N.I.,Siderovski, D.P. A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis Plos Pathog., 8:e1002553-e1002553, 2012 Cited by PubMed: 22383884 DOI: 10.1371/journal.ppat.1002553 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.797 Å)

Structure validation