3QI2

A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco

3QI2 の概要

• エントリーDOI: 10.2210/pdb3qi2/pdb
• 関連するPDBエントリー: 1kjy 1Y3A 2OM2 3QE0
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• 機能のキーワード: rgs14 goloco, ras-like domain, all-helical domain, goloco motif, arginine finger, signaling protein, lipoprotein, transducer, guanine nucleotide dissociation inhibitor, gtp binding, nucleotide binding, adp-ribosylation
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus (By similarity): P63096 O43566
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 84421.36

構造登録者

Bosch, D.E.,Willard, F.S.,Kimple, A.J.,Miley, M.J.,Siderovski, D.P. (登録日: 2011-01-26, 公開日: 2012-02-01, 最終更新日: 2023-09-13)

• 主引用文献: Bosch, D.E.,Willard, F.S.,Ramanujam, R.,Kimple, A.J.,Willard, M.D.,Naqvi, N.I.,Siderovski, D.P.; A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis; Plos Pathog., 8:e1002553-e1002553, 2012; PubMed: 22383884; DOI: 10.1371/journal.ppat.1002553

実験手法

X-RAY DIFFRACTION (2.797 Å)