3QI0

Structural, thermodynamic and kinetic analysis of the picomolar binding affinity interaction of the beta-lactamase inhibitor protein-II (BLIP-II) with class A beta-lactamases

Summary for 3QI0

• Entry DOI: 10.2210/pdb3qi0/pdb
• Related: 1jtd 1jtg 3QHY
• Descriptor: Beta-lactamase inhibitory protein II, SULFATE ION (3 entities in total)
• Functional Keywords: enzyme-inhibitor complex, bsgc, beta-propeller, beta-lactamase, protein:protein interaction, hydrolase inhibitor
• Biological source: Streptomyces exfoliatus (Streptomyces hydrogenans)
• Total number of polymer chains: 6
• Total formula weight: 173527.89

Authors

Brown, N.G.,Chow, D.C.,Sankaran, B.,Zwart, P.,Prasad, B.V.V.,Palzkill, T. (deposition date: 2011-01-26, release date: 2011-07-20, Last modification date: 2024-02-21)

• Primary citation: Brown, N.G.,Chow, D.C.,Sankaran, B.,Zwart, P.,Prasad, B.V.,Palzkill, T.; Analysis of the binding forces driving the tight interactions between beta-lactamase inhibitory protein-II (BLIP-II) and class A beta-lactamases.; J.Biol.Chem., 286:32723-32735, 2011; PubMed: 21775426; DOI: 10.1074/jbc.M111.265058

Experimental method

X-RAY DIFFRACTION (2.8 Å)