3QE0

A Galpha-i1 P-loop mutation prevents transition to the activated state

3QE0 の概要

• エントリーDOI: 10.2210/pdb3qe0/pdb
• 関連するPDBエントリー: 1Y3A 1kjy 2OM2 3QI2
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-1, KB752 peptide, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: kb752, ras-like domain, all-helical domain, arginine finger, signaling protein, lipoprotein, transducer, gtpase activity, gtp binding, nucleotide binding, adp-ribosylation
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus (By similarity): P63096
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 117216.34

構造登録者

Bosch, D.E.,Willard, F.S.,Kimple, A.J.,Miley, M.J.,Siderovski, D.P. (登録日: 2011-01-19, 公開日: 2012-01-25, 最終更新日: 2023-09-13)

• 主引用文献: Bosch, D.E.,Willard, F.S.,Ramanujam, R.,Kimple, A.J.,Willard, M.D.,Naqvi, N.I.,Siderovski, D.P.; A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis; Plos Pathog., 8:e1002553-e1002553, 2012; PubMed: 22383884; DOI: 10.1371/journal.ppat.1002553

実験手法

X-RAY DIFFRACTION (3 Å)