3QCG
Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 3-[(3-bromo-4-chlorobenzyl)sulfanyl]thiophene-2-carboxylic acid
Summary for 3QCG
Entry DOI | 10.2210/pdb3qcg/pdb |
Related | 3QCB 3QCC 3QCD 3QCE 3QCF 3QCH 3QCI 3QCJ 3QCK 3QCL 3QCM 3QCN |
Descriptor | Receptor-type tyrosine-protein phosphatase gamma, 3-[(3-bromo-4-chlorobenzyl)sulfanyl]thiophene-2-carboxylic acid, ACETIC ACID, ... (4 entities in total) |
Functional Keywords | tyrosine receptor phosphatase, twisted mixed beta-sheets flanked by {alpha}-helices, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein (Probable): P23470 |
Total number of polymer chains | 1 |
Total formula weight | 36131.30 |
Authors | Sheriff, S. (deposition date: 2011-01-16, release date: 2011-12-28, Last modification date: 2023-09-13) |
Primary citation | Sheriff, S.,Beno, B.R.,Zhai, W.,Kostich, W.A.,McDonnell, P.A.,Kish, K.,Goldfarb, V.,Gao, M.,Kiefer, S.E.,Yanchunas, J.,Huang, Y.,Shi, S.,Zhu, S.,Dzierba, C.,Bronson, J.,Macor, J.E.,Appiah, K.K.,Westphal, R.S.,O'Connell, J.,Gerritz, S.W. Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop J.Med.Chem., 54:6548-6562, 2011 Cited by PubMed: 21882820DOI: 10.1021/jm2003766 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
Download full validation report