3PZ2

Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP

Summary for 3PZ2

• Entry DOI: 10.2210/pdb3pz2/pdb
• Related: 3PZ1 3PZ3 3PZ4
• Descriptor: Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, ZINC ION, ... (7 entities in total)
• Functional Keywords: protein prenylation, fusion protein, chimera protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Rattus norvegicus (rat); More
• Total number of polymer chains: 2
• Total formula weight: 76343.18

Authors

Guo, Z.,Bon, R.S.,Stigter, E.A.,Waldmann, H.,Alexandrov, K.,Blankenfeldt, W.,Goody, R.S. (deposition date: 2010-12-14, release date: 2011-05-11, Last modification date: 2023-09-13)

• Primary citation: Bon, R.S.,Guo, Z.,Stigter, E.A.,Wetzel, S.,Menninger, S.,Wolf, A.,Choidas, A.,Alexandrov, K.,Blankenfeldt, W.,Goody, R.S.,Waldmann, H.; Structure-Guided Development of Selective RabGGTase Inhibitors.; Angew.Chem.Int.Ed.Engl., 50:4957-4961, 2011; PubMed: 21520375; DOI: 10.1002/anie.201101210

Experimental method

X-RAY DIFFRACTION (2.35 Å)