3PZ2

Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Geranylgeranyl transferase type-2 subunit alpha	polymer	332	38498.7	1	UniProt (Q08602) Pfam (PF01239)	Rattus norvegicus (rat)	Geranylgeranyl transferase type II subunit alpha, Rab geranyl-geranyltransferase subunit alpha, Rab GG transferase alpha, Rab GGTase alpha, Rab geranylgeranyltransferase subunit alpha
2	B (B)	Geranylgeranyl transferase type-2 subunit beta	polymer	330	36761.0	1	UniProt (Q08603) Pfam (PF00432)	Rattus norvegicus (rat)	Geranylgeranyl transferase type II subunit beta, GGTase-II-beta, Rab geranyl-geranyltransferase subunit beta, Rab GG transferase beta, Rab GGTase beta, Rab geranylgeranyltransferase subunit beta, Type II protein geranyl-geranyltransferase subunit beta
3	C (B)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	D (B)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
5	E (B)	(3R)-3-benzyl-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile	non-polymer		527.6	1	Chemie (3PZ)
6	F (B)	GERANYLGERANYL DIPHOSPHATE	non-polymer		450.4	1	Chemie (GRG)
7	G, H (A, B)	water	water		18.0	183	Chemie (HOH)

Sequence modifications

A: 1 - 237 (UniProt: Q08602)

PDB	External Database	Details
Gly -1	-	expression tag
His 0	-	expression tag

A: 242 - 330 (UniProt: Q08602)

PDB	External Database	Details
Ala 238	-	linker
Gly 239	-	linker
Ser 240	-	linker
Gly 241	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75259.6
Non-Polymers*	Number of molecules	4
	Total formula weight	1083.6
All*	Total formula weight	76343.2

*Water molecules are not included.