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3PYY

Discovery and Characterization of a Cell-Permeable, Small-molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site

Summary for 3PYY
Entry DOI10.2210/pdb3pyy/pdb
DescriptorV-abl Abelson murine leukemia viral oncogene homolog 1 isoform b variant, SULFATE ION, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ... (7 entities in total)
Functional Keywordstyrosine kinase, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight71871.75
Authors
Yang, J.,Campobasso, N.,Biju, M.P.,Fisher, K.,Pan, X.Q.,Cottom, J.,Galbraith, S.,Ho, T.,Zhang, H.,Hong, X.,Ward, P.,Hofmann, G.,Siegfried, B. (deposition date: 2010-12-13, release date: 2011-03-09, Last modification date: 2024-02-21)
Primary citationYang, J.,Campobasso, N.,Biju, M.P.,Fisher, K.,Pan, X.Q.,Cottom, J.,Galbraith, S.,Ho, T.,Zhang, H.,Hong, X.,Ward, P.,Hofmann, G.,Siegfried, B.,Zappacosta, F.,Washio, Y.,Cao, P.,Qu, J.,Bertrand, S.,Wang, D.Y.,Head, M.S.,Li, H.,Moores, S.,Lai, Z.,Johanson, K.,Burton, G.,Erickson-Miller, C.,Simpson, G.,Tummino, P.,Copeland, R.A.,Oliff, A.
Discovery and Characterization of a Cell-Permeable, Small-Molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site.
Chem.Biol., 18:177-186, 2011
Cited by
PubMed: 21338916
DOI: 10.1016/j.chembiol.2010.12.013
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

217705

건을2024-03-27부터공개중

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