3PMW

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

3PMW の概要

• エントリーDOI: 10.2210/pdb3pmw/pdb
• 関連するPDBエントリー: 3O28 3O29 3O2A 3O6G 3O6H 3O6I 3PMV 3PMX
• 分子名称: Glutamate receptor 2, GLUTAMIC ACID, SULFATE ION, ... (7 entities in total)
• 機能のキーワード: transport protein, membrane protein, fusion protein, chimera protein
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30677.01

構造登録者

Maclean, J.K.F.,Jamieson, C.,Brown, C.I.,Campbell, R.A.,Gillen, K.J.,Gillespie, J.,Kazemier, B.,Kiczun, M.,Lamont, Y.,Lyons, A.J.,Moir, E.M.,Morrow, J.A.,Pantling, J.,Rankovic, Z.,Smith, L. (登録日: 2010-11-18, 公開日: 2011-01-12, 最終更新日: 2024-11-20)

主引用文献

Jamieson, C.,Maclean, J.K.,Brown, C.I.,Campbell, R.A.,Gillen, K.J.,Gillespie, J.,Kazemier, B.,Kiczun, M.,Lamont, Y.,Lyons, A.J.,Moir, E.M.,Morrow, J.A.,Pantling, J.,Rankovic, Z.,Smith, L.
Structure based evolution of a novel series of positive modulators of the AMPA receptor.
Bioorg.Med.Chem.Lett., 21:805-811, 2011

PubMed Abstract: Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotype with a promising overall profile, exemplified by 19.

PubMed: 21190850
DOI: 10.1016/j.bmcl.2010.11.098

実験手法

X-RAY DIFFRACTION (2.2 Å)