3PMW
Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glutamate receptor 2 | polymer | 263 | 29177.7 | 1 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (brown rat rat rats) | GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2 |
| 2 | B (A) | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
| 3 | C, D, E, F, G... (A) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 4 | J, K (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | L (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | M (A) | N-[(2S)-5-{[4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2,3-dihydro-1H-inden-2-yl]propane-2-sulfonami de | non-polymer | 417.4 | 1 | Chemie (G69) | |||
| 7 | N (A) | water | water | 18.0 | 148 | Chemie (HOH) |
Sequence modifications
A: 4 - 118 (UniProt: P19491)
A: 121 - 264 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly 2 | - | expression tag |
| Ala 3 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 119 | - | expression tag |
| Thr 120 | - | expression tag |
| Thr 233 | Asn 765 | conflict |
| Pro 234 | Ala 766 | conflict |
| Ser 243 | Asn 775 | conflict |
| Val 247 | Leu 779 | conflict |
| Ala 264 | Ser 796 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29177.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1499.3 | |
| All* | Total formula weight | 30677.0 |
