3PMW
Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Glutamate receptor 2 | polymer | 263 | 29177.7 | 1 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (brown rat rat rats) | GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2 |
2 | A | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
3 | A | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
5 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
6 | A | N-[(2S)-5-{[4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2,3-dihydro-1H-inden-2-yl]propane-2-sulfonami de | non-polymer | 417.4 | 1 | Chemie (G69) | |||
7 | water | water | 18.0 | 148 | Chemie (HOH) |
Sequence modifications
A: 4 - 118 (UniProt: P19491)
A: 121 - 264 (UniProt: P19491)
PDB | External Database | Details |
---|---|---|
Gly 2 | - | expression tag |
Ala 3 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 119 | - | expression tag |
Thr 120 | - | expression tag |
Thr 233 | Asn 765 | conflict |
Pro 234 | Ala 766 | conflict |
Ser 243 | Asn 775 | conflict |
Val 247 | Leu 779 | conflict |
Ala 264 | Ser 796 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 29177.7 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1499.3 | |
All* | Total formula weight | 30677.0 |