3PFV
Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
Summary for 3PFV
Entry DOI | 10.2210/pdb3pfv/pdb |
Descriptor | E3 ubiquitin-protein ligase CBL-B, 11-meric peptide from Epidermal growth factor receptor, SODIUM ION, ... (8 entities in total) |
Functional Keywords | structural genomics, structural genomics consortium, sgc, signal transduction protein, cbl-b, sh3-binding protein, ligase-protein binding complex, ligase/protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: Q13191 Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 4 |
Total formula weight | 77583.04 |
Authors | Chaikuad, A.,Guo, K.,Cooper, C.D.O.,Ayinampudi, V.,Krojer, T.,Muniz, J.R.C.,Vollmar, M.,Canning, P.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2010-10-29, release date: 2010-12-08, Last modification date: 2023-12-06) |
Primary citation | Chaikuad, A.,Guo, K.,Cooper, C.D.O.,Ayinampudi, V.,Krojer, T.,Muniz, J.R.C.,Vollmar, M.,Canning, P.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide To be Published, |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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