3PFV

Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide

3PFV の概要

• エントリーDOI: 10.2210/pdb3pfv/pdb
• 分子名称: E3 ubiquitin-protein ligase CBL-B, 11-meric peptide from Epidermal growth factor receptor, SODIUM ION, ... (8 entities in total)
• 機能のキーワード: structural genomics, structural genomics consortium, sgc, signal transduction protein, cbl-b, sh3-binding protein, ligase-protein binding complex, ligase/protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: Q13191; Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 77583.04

構造登録者

Chaikuad, A.,Guo, K.,Cooper, C.D.O.,Ayinampudi, V.,Krojer, T.,Muniz, J.R.C.,Vollmar, M.,Canning, P.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (登録日: 2010-10-29, 公開日: 2010-12-08, 最終更新日: 2023-12-06)

• 主引用文献: Chaikuad, A.,Guo, K.,Cooper, C.D.O.,Ayinampudi, V.,Krojer, T.,Muniz, J.R.C.,Vollmar, M.,Canning, P.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC); Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide; To be Published,

実験手法

X-RAY DIFFRACTION (2.27 Å)