3PB6

Crystal structure of the catalytic domain of human Golgi-resident glutaminyl cyclase at pH 6.5

Summary for 3PB6

Entry DOI	10.2210/pdb3pb6/pdb
Related	3PB4 3PB7 3PB8 3PB9 3PBB 3PBE
Descriptor	Glutaminyl-peptide cyclotransferase-like protein, CACODYLATE ION, ZINC ION, ... (4 entities in total)
Functional Keywords	alpha/beta protein, alpha/beta-mixed fold, glutaminyl cyclase, golgi membrane, transferase
Biological source	Homo sapiens (human)
Cellular location	Golgi apparatus membrane; Single-pass type I membrane protein: Q9NXS2
Total number of polymer chains	1
Total formula weight	37271.13
Authors	Huang, K.F.,Liaw, S.S.,Huang, W.L.,Chia, C.Y.,Lo, Y.C.,Chen, Y.L.,Wang, A.H.J. (deposition date: 2010-10-20, release date: 2011-02-02, Last modification date: 2023-11-01)
Primary citation	Huang, K.F.,Liaw, S.S.,Huang, W.L.,Chia, C.Y.,Lo, Y.C.,Chen, Y.L.,Wang, A.H.J. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding J.Biol.Chem., 286:12439-12449, 2011 Cited by PubMed: 21288892 DOI: 10.1074/jbc.M110.208595 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.05 Å)

Structure validation