3PB4
Crystal structure of the catalytic domain of human Golgi-resident glutaminyl cyclase at pH 6.0
Summary for 3PB4
Entry DOI | 10.2210/pdb3pb4/pdb |
Related | 3PB6 3PB7 3PB8 3PB9 3PBB 3PBE |
Descriptor | Glutaminyl-peptide cyclotransferase-like protein, ZINC ION (3 entities in total) |
Functional Keywords | alpha/beta protein, alpha/beta-mixed fold, glutaminyl cyclase, golgi membrane, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Golgi apparatus membrane; Single-pass type I membrane protein: Q9NXS2 |
Total number of polymer chains | 1 |
Total formula weight | 37134.14 |
Authors | Huang, K.F.,Liaw, S.S.,Huang, W.L.,Chia, C.Y.,Lo, Y.C.,Chen, Y.L.,Wang, A.H.J. (deposition date: 2010-10-20, release date: 2011-02-02, Last modification date: 2024-03-20) |
Primary citation | Huang, K.F.,Liaw, S.S.,Huang, W.L.,Chia, C.Y.,Lo, Y.C.,Chen, Y.L.,Wang, A.H.J. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding J.Biol.Chem., 286:12439-12449, 2011 Cited by PubMed: 21288892DOI: 10.1074/jbc.M110.208595 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.13 Å) |
Structure validation
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