3PBE
Crystal structure of the mutant W207F of human secretory glutaminyl cyclase
Summary for 3PBE
Entry DOI | 10.2210/pdb3pbe/pdb |
Related | 2AFM 3PB4 3PB6 3PB7 3PB8 3PB9 3PBB |
Descriptor | Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION, ... (4 entities in total) |
Functional Keywords | alpha/beta protein, alpha/beta-mixed fold, glutaminyl cyclase, secretory pathway, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: Q16769 |
Total number of polymer chains | 2 |
Total formula weight | 75359.67 |
Authors | Huang, K.F.,Liaw, S.S.,Huang, W.L.,Chia, C.Y.,Lo, Y.C.,Chen, Y.L.,Wang, A.H.J. (deposition date: 2010-10-20, release date: 2011-02-02, Last modification date: 2023-11-01) |
Primary citation | Huang, K.F.,Liaw, S.S.,Huang, W.L.,Chia, C.Y.,Lo, Y.C.,Chen, Y.L.,Wang, A.H.J. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding J.Biol.Chem., 286:12439-12449, 2011 Cited by PubMed: 21288892DOI: 10.1074/jbc.M110.208595 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
Download full validation report