3P70

Structural basis of thrombin-mediated factor V activation: essential role of the hirudin-like sequence Glu666-Glu672 for processing at the heavy chain-B domain junction

Summary for 3P70

• Entry DOI: 10.2210/pdb3p70/pdb
• Related: 1DX5 1E0F 1NU7 1PPB 2PW8 3LU9 3P6Z
• Descriptor: HUMAN ALPHA-THROMBIN, LIGHT CHAIN, HUMAN ALPHA-THROMBIN, HEAVY CHAIN, HUMAN FACTOR V, A2-B DOMAIN LINKER, ... (9 entities in total)
• Functional Keywords: trypsin-like serine proteinase, blood coagulation, n-glycosylation, blood plasma, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 171547.98

Authors

Corral-Rodriguez, M.A.,Bock, P.E.,Hernandez-Carvajal, E.,Gutierrez-Gallego, R.,Fuentes-Prior, P. (deposition date: 2010-10-11, release date: 2011-09-28, Last modification date: 2023-09-06)

• Primary citation: Corral-Rodriguez, M.A.,Bock, P.E.,Hernandez-Carvajal, E.,Gutierrez-Gallego, R.,Fuentes-Prior, P.; Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction.; Blood, 117:7164-7173, 2011; PubMed: 21555742; DOI: 10.1182/blood-2010-10-315309

Experimental method

X-RAY DIFFRACTION (2.55 Å)