3P6A

Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant)

Summary for 3P6A

• Entry DOI: 10.2210/pdb3p6a/pdb
• Related: 1TXD 1X86 1XCG 3ODO 3ODW 3ODX
• Descriptor: Rho guanine nucleotide exchange factor 1 (1 entity in total)
• Functional Keywords: regulation of rhoa gtpase, rhogef, dh, ph, rho, signaling protein
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q92888
• Total number of polymer chains: 2
• Total formula weight: 87823.33

Authors

Chen, Z.,Guo, L.,Sprang, S.R.,Sternweis, P.C. (deposition date: 2010-10-11, release date: 2011-01-05, Last modification date: 2023-09-06)

• Primary citation: Chen, Z.,Guo, L.,Sprang, S.R.,Sternweis, P.C.; Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF; Protein Sci., 20:107-117, 2011

Experimental method

X-RAY DIFFRACTION (2.5 Å)