3P6A
Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Rho guanine nucleotide exchange factor 1 | polymer | 377 | 43911.7 | 2 | UniProt (Q92888) Pfam (PF00621) Pfam (PF17838) In PDB | Homo sapiens (human) | 115 kDa guanine nucleotide exchange factor, p115-RhoGEF, p115RhoGEF, Sub1.5 |
Sequence modifications
A, B: 395 - 766 (UniProt: Q92888)
| PDB | External Database | Details |
|---|---|---|
| Gly 390 | - | expression tag |
| Ile 391 | - | expression tag |
| Gln 392 | - | expression tag |
| Thr 393 | - | expression tag |
| Ser 394 | - | expression tag |
| Glu 399 | Arg 399 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 87823.3 | |
| All* | Total formula weight | 87823.3 |
