3OZ1

cIAP1-BIR3 domain in complex with the Smac-mimetic compound Smac066

Summary for 3OZ1

• Entry DOI: 10.2210/pdb3oz1/pdb
• Related: 3MUP
• Descriptor: Baculoviral IAP repeat-containing protein 2, ZINC ION, (3S,6S,7R,9aS)-7-[2-(benzylamino)ethyl]-N-(diphenylmethyl)-6-{[(2S)-2-(methylamino)butanoyl]amino}-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide, ... (4 entities in total)
• Functional Keywords: zinc-finger, caspases, apoptosis inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (Potential): Q13490
• Total number of polymer chains: 4
• Total formula weight: 60261.80

Authors

Cossu, F.,Malvezzi, F.,Mastrangelo, E.,Canevari, G.,Bolognesi, M.,Milani, M. (deposition date: 2010-09-24, release date: 2010-11-24, Last modification date: 2024-03-20)

• Primary citation: Cossu, F.,Malvezzi, F.,Canevari, G.,Mastrangelo, E.,Lecis, D.,Delia, D.,Seneci, P.,Scolastico, C.,Bolognesi, M.,Milani, M.; Recognition of Smac-mimetic compounds by the BIR3 domain of cIAP1; Protein Sci., 2010; PubMed: 20954235; DOI: 10.1002/pro.523

Experimental method

X-RAY DIFFRACTION (3 Å)