3MUP

cIAP1-BIR3 domain in complex with the Smac-mimetic compound Smac037

Summary for 3MUP

• Entry DOI: 10.2210/pdb3mup/pdb
• Related: 3EYL 3OZ1
• Descriptor: Baculoviral IAP repeat-containing protein 2, (3S,6S,7R,9aS)-6-{[(2S)-2-aminobutanoyl]amino}-7-(2-aminoethyl)-N-(diphenylmethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide, ZINC ION, ... (4 entities in total)
• Functional Keywords: zinc-finger motif, apoptosis inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q13490
• Total number of polymer chains: 4
• Total formula weight: 59845.21

Authors

Cossu, F.,Malvezzi, F.,Canevari, G.,Milani, M. (deposition date: 2010-05-03, release date: 2010-11-24, Last modification date: 2023-11-01)

• Primary citation: Cossu, F.,Malvezzi, F.,Canevari, G.,Mastrangelo, E.,Lecis, D.,Delia, D.,Seneci, P.,Scolastico, C.,Bolognesi, M.,Milani, M.; Recognition of Smac-mimetic compounds by the BIR domain of cIAP1; Protein Sci., 19:2418-2429, 2010; PubMed: 20954235; DOI: 10.1002/pro.523

Experimental method

X-RAY DIFFRACTION (2.6 Å)