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3OYS

Human Carbonic Anhydrase II complexed with 2-{[4-AMINO-3-(3-HYDROXYPROP-1-YN-1-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]METHYL}-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE

Summary for 3OYS
Entry DOI10.2210/pdb3oys/pdb
Related3OY0 3OYQ
DescriptorCarbonic anhydrase 2, GLYCEROL, ZINC ION, ... (6 entities in total)
Functional Keywordsbenzene sulphonamide inhibitor, drug interactions, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : P00918
Total number of polymer chains1
Total formula weight29815.04
Authors
Aggarwal, M.,McKenna, R. (deposition date: 2010-09-23, release date: 2011-08-10, Last modification date: 2024-02-21)
Primary citationHen, N.,Bialer, M.,Yagen, B.,Maresca, A.,Aggarwal, M.,Robbins, A.H.,McKenna, R.,Scozzafava, A.,Supuran, C.T.
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.
J.Med.Chem., 54:3977-3981, 2011
Cited by
PubMed: 21506569
DOI: 10.1021/jm200209n
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.538 Å)
Structure validation

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