3OY0
Human Carbonic Anhydrase II complexed with 1-(4-(4-(2-(ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)-3-METHOXYPHENYL)PIPERIDIN-4-OL
Summary for 3OY0
Entry DOI | 10.2210/pdb3oy0/pdb |
Related | 3OYQ 3OYS |
Descriptor | Carbonic anhydrase 2, ZINC ION, (2S)-2-tert-butyl-N-(4-sulfamoylphenyl)pentanamide, ... (6 entities in total) |
Functional Keywords | benzene sulfonamide, drug interaction, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29837.13 |
Authors | Aggarwal, M.,McKenna, R. (deposition date: 2010-09-22, release date: 2011-08-10, Last modification date: 2023-09-06) |
Primary citation | Hen, N.,Bialer, M.,Yagen, B.,Maresca, A.,Aggarwal, M.,Robbins, A.H.,McKenna, R.,Scozzafava, A.,Supuran, C.T. Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV. J.Med.Chem., 54:3977-3981, 2011 Cited by PubMed: 21506569DOI: 10.1021/jm200209n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report