3OYQ

Structure of Human Carbonic Anhydrase II complexed with 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE

Summary for 3OYQ

Entry DOI	10.2210/pdb3oyq/pdb
Related	3OY0 3OYS
Descriptor	Carbonic anhydrase 2, ZINC ION, (4S)-4-methyl-N-(4-sulfamoylphenyl)hexanamide, ... (6 entities in total)
Functional Keywords	benzene sulphonamide inhibitor, drug interactions, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29809.07
Authors	Aggarwal, M.,McKenna, R. (deposition date: 2010-09-23, release date: 2011-08-10, Last modification date: 2024-02-21)
Primary citation	Hen, N.,Bialer, M.,Yagen, B.,Maresca, A.,Aggarwal, M.,Robbins, A.H.,McKenna, R.,Scozzafava, A.,Supuran, C.T. Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV. J.Med.Chem., 54:3977-3981, 2011 Cited by PubMed: 21506569 DOI: 10.1021/jm200209n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.47 Å)

Structure validation