3OYN
Crystal structure of the PFV N224H mutant intasome bound to magnesium and the INSTI MK2048
3OYN の概要
エントリーDOI | 10.2210/pdb3oyn/pdb |
関連するPDBエントリー | 3DLR 3L2Q 3L2R 3L2U 3L2V 3L2W 3OY9 3OYA 3OYB 3OYC 3OYD 3OYE 3OYF 3OYG 3OYH 3OYI 3OYJ 3OYK 3OYL 3OYM |
分子名称 | PFV integrase, DNA (5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'), ... (10 entities in total) |
機能のキーワード | protein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna-binding, zinc binding, hhcc motif, viral protein, recombination, inhibitor, dna-binding protein-dna complex, viral protein-dna complex, viral protein/dna |
由来する生物種 | Human spumaretrovirus (SFVcpz(hu)) 詳細 |
細胞内の位置 | Integrase: Virion (Potential). Protease/Reverse transcriptase/ribonuclease H: Host nucleus (By similarity): P14350 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 101242.16 |
構造登録者 | |
主引用文献 | Hare, S.,Vos, A.M.,Clayton, R.F.,Thuring, J.W.,Cummings, M.D.,Cherepanov, P. Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. Proc.Natl.Acad.Sci.USA, 107:20057-20062, 2010 Cited by PubMed: 21030679DOI: 10.1073/pnas.1010246107 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.68 Å) |
構造検証レポート
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