3OY5

The crystal structure of uPA complex with peptide inhibitor MH027 at pH7.4

Summary for 3OY5

• Entry DOI: 10.2210/pdb3oy5/pdb
• Related: 2NWN 3OX7 3OY6
• Descriptor: Urokinase-type plasminogen activator, MH027, SULFATE ION, ... (4 entities in total)
• Functional Keywords: urokinase-type plasminogen activator, peptidyl inhibitor, pharmacophore, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00749
• Total number of polymer chains: 2
• Total formula weight: 30792.94

Authors

Jiang, L.G.,Andreasen, P.A.,Huang, M.D. (deposition date: 2010-09-22, release date: 2011-08-10, Last modification date: 2023-11-01)

• Primary citation: Jiang, L.G.,Svane, A.S.P.,Sorensen, H.P.,Jensen, J.K.,Hosseini, M.,Chen, Z.,Weydert, C.,Nielsen, J.T.,Christensen, A.,Yuan, C.,Jensen, K.J.,Nielsen, N.C.,Malmendal, A.,Huang, M.D.,Andreasen, P.A.; The binding mechanism of a peptidic cyclic serine protease inhibitor; J.Mol.Biol., 412:235-250, 2011; PubMed: 21802428; DOI: 10.1016/j.jmb.2011.07.028

Experimental method

X-RAY DIFFRACTION (2.31 Å)