3OXX

Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Atazanavir

3OXX の概要

• エントリーDOI: 10.2210/pdb3oxx/pdb
• 関連するPDBエントリー: 3OXV 3OXW 3OY4
• 分子名称: HIV-1 PROTEASE, GLYCEROL, 1,2-ETHANEDIOL, ... (7 entities in total)
• 機能のキーワード: hiv-1 protease, inhibitor resistance, aids, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: HIV-1 M:B_ARV2/SF2 (HIV-1)
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 45860.87

構造登録者

Schiffer, C.A.,Bandaranayake, R.M. (登録日: 2010-09-22, 公開日: 2011-09-28, 最終更新日: 2023-09-06)

• 主引用文献: Mittal, S.,Bandaranayake, R.M.,King, N.M.,Prabu-Jeyabalan, M.,Nalam, M.N.,Nalivaika, E.A.,Yilmaz, N.K.,Schiffer, C.A.; Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.; J.Virol., 87:4176-4184, 2013; PubMed: 23365446; DOI: 10.1128/JVI.03486-12

実験手法

X-RAY DIFFRACTION (1.65 Å)