3OXW
Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Darunavir
3OXW の概要
エントリーDOI | 10.2210/pdb3oxw/pdb |
関連するPDBエントリー | 3OXV 3OXX 3OY4 |
分子名称 | HIV-1 Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, PHOSPHATE ION, ... (7 entities in total) |
機能のキーワード | hiv-1 protease, inhibitor resistance, aids, aspartyl protease, drug resistance, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | HIV-1 M:B_ARV2/SF2 (HIV-1) |
細胞内の位置 | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 45558.29 |
構造登録者 | |
主引用文献 | Mittal, S.,Bandaranayake, R.M.,King, N.M.,Prabu-Jeyabalan, M.,Nalam, M.N.,Nalivaika, E.A.,Yilmaz, N.K.,Schiffer, C.A. Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50. J.Virol., 87:4176-4184, 2013 Cited by PubMed: 23365446DOI: 10.1128/JVI.03486-12 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.95 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード