3OCT

Crystal structure of bruton's tyrosine kinase mutant V555R in complex with dasatinib

Summary for 3OCT

• Entry DOI: 10.2210/pdb3oct/pdb
• Related: 3OCS
• Descriptor: Tyrosine-protein kinase BTK, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (3 entities in total)
• Functional Keywords: tyrosine kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): Q06187
• Total number of polymer chains: 1
• Total formula weight: 31465.67

Authors

Davies, D.R.,Staker, B.L. (deposition date: 2010-08-10, release date: 2010-11-03, Last modification date: 2023-09-06)

• Primary citation: Di Paolo, J.A.,Huang, T.,Balazs, M.,Barbosa, J.,Barck, K.H.,Carano, R.A.D.,Darrow, J.,Davies, D.R.,DeForge, L.E.,Dennis Jr., G.,Diehl, L.,Ferrando, R.; A novel, specific Btk inhibitor antagonizes BCR and Fc[gamma]R signaling and suppresses inflammatory arthritis; To be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)