3OCT
Crystal structure of bruton's tyrosine kinase mutant V555R in complex with dasatinib
Summary for 3OCT
Entry DOI | 10.2210/pdb3oct/pdb |
Related | 3OCS |
Descriptor | Tyrosine-protein kinase BTK, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (3 entities in total) |
Functional Keywords | tyrosine kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q06187 |
Total number of polymer chains | 1 |
Total formula weight | 31465.67 |
Authors | Davies, D.R.,Staker, B.L. (deposition date: 2010-08-10, release date: 2010-11-03, Last modification date: 2023-09-06) |
Primary citation | Di Paolo, J.A.,Huang, T.,Balazs, M.,Barbosa, J.,Barck, K.H.,Carano, R.A.D.,Darrow, J.,Davies, D.R.,DeForge, L.E.,Dennis Jr., G.,Diehl, L.,Ferrando, R. A novel, specific Btk inhibitor antagonizes BCR and Fc[gamma]R signaling and suppresses inflammatory arthritis To be Published, |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
Download full validation report