3OCS

Crystal structure of bruton's tyrosine kinase in complex with inhibitor CGI1746

Summary for 3OCS

• Entry DOI: 10.2210/pdb3ocs/pdb
• Related: 3OCT
• Descriptor: Tyrosine-protein kinase BTK, SULFATE ION, BETA-MERCAPTOETHANOL, ... (5 entities in total)
• Functional Keywords: tyrosine kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): Q06187
• Total number of polymer chains: 1
• Total formula weight: 32644.48

Authors

Davies, D.R.,Gallion, S.L.,Staker, B.L. (deposition date: 2010-08-10, release date: 2010-11-03, Last modification date: 2023-09-06)

• Primary citation: Di Paolo, J.A.,Huang, T.,Balazs, M.,Barbosa, J.,Barck, K.H.,Carano, R.A.D.,Darrow, J.,Davies, D.R.,DeForge, L.E.,Dennis Jr., G.,Diehl, L.,Ferrando, R.; A novel, specific Btk inhibitor antagonizes BCR and Fc[gamma]R signaling and suppresses inflammatory arthritis; To be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)