3OCT
Crystal structure of bruton's tyrosine kinase mutant V555R in complex with dasatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase BTK | polymer | 265 | 30977.7 | 1 | UniProt (Q06187) Pfam (PF07714) | Homo sapiens (human) | Bruton tyrosine kinase, Agammaglobulinaemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK |
| 2 | B (A) | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE | non-polymer | 488.0 | 1 | Chemie (1N1) | |||
| 3 | C (A) | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A: 393 - 656 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Gly 392 | - | expression tag |
| Arg 555 | Val 555 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30977.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 488.0 | |
| All* | Total formula weight | 31465.7 |
