3O9E

Crystal Structure of wild-type HIV-1 Protease in complex with af60

Summary for 3O9E

Entry DOI	10.2210/pdb3o9e/pdb
Related	3O99 3O9A 3O9B 3O9C 3O9D 3O9F 3O9G 3O9H 3O9I
Descriptor	Pol polyprotein, PHOSPHATE ION, ACETATE ION, ... (5 entities in total)
Functional Keywords	hiv-1 protease, drug resistance, drug design, protease inhibitors, aids, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1 (HIV-1)
Total number of polymer chains	2
Total formula weight	22646.23
Authors	Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2010-08-04, release date: 2011-08-10, Last modification date: 2024-04-03)
Primary citation	Nalam, M.N.,Ali, A.,Reddy, G.S.,Cao, H.,Anjum, S.G.,Altman, M.D.,Yilmaz, N.K.,Tidor, B.,Rana, T.M.,Schiffer, C.A. Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chem.Biol., 20:1116-1124, 2013 Cited by PubMed: 24012370 DOI: 10.1016/j.chembiol.2013.07.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation