3O9A
Crystal Structure of wild-type HIV-1 Protease in complex with kd14
Summary for 3O9A
Entry DOI | 10.2210/pdb3o9a/pdb |
Related | 3O99 3O9B 3O9C 3O9D 3O9E 3O9F 3O9G 3O9H 3O9I |
Descriptor | Pol polyprotein, PHOSPHATE ION, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino}propyl]carbamate, ... (4 entities in total) |
Functional Keywords | hiv-1 protease, drug resistance, drug design, protease inhibitors, aids, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 (HIV-1) |
Total number of polymer chains | 2 |
Total formula weight | 22588.17 |
Authors | Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2010-08-04, release date: 2011-08-10, Last modification date: 2024-04-03) |
Primary citation | Nalam, M.N.,Ali, A.,Reddy, G.S.,Cao, H.,Anjum, S.G.,Altman, M.D.,Yilmaz, N.K.,Tidor, B.,Rana, T.M.,Schiffer, C.A. Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chem.Biol., 20:1116-1124, 2013 Cited by PubMed: 24012370DOI: 10.1016/j.chembiol.2013.07.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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