3O6I

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

3O6I の概要

• エントリーDOI: 10.2210/pdb3o6i/pdb
• 関連するPDBエントリー: 3O28 3O29 3O2A 3O6G 3O6H 3PMV 3PMW 3PMX
• 分子名称: Glutamate receptor 2, GLUTAMIC ACID, 2-[({3-tert-butyl-4-[(methylamino)methyl]-1H-pyrazol-1-yl}acetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, ... (5 entities in total)
• 機能のキーワード: transport protein, membrane protein, fusion protein, chimera protein
• 由来する生物種: Rattus norvegicus (rat); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30208.66

構造登録者

Maclean, J.K.F.,Campbell, R.A.,Cumming, I.A.,Gillen, K.J.,Gillespie, J.,Jamieson, C.,Kazemier, B.,Kiczun, M.,Lamont, Y.,Lyons, A.J.,Martin, F.,Moir, E.M.,Morrow, J.A.,Pantling, J.,Rankovic, Z.,Smith, L. (登録日: 2010-07-29, 公開日: 2010-09-15, 最終更新日: 2024-11-27)

主引用文献

Jamieson, C.,Campbell, R.A.,Cumming, I.A.,Gillen, K.J.,Gillespie, J.,Kazemier, B.,Kiczun, M.,Lamont, Y.,Lyons, A.J.,Maclean, J.K.,Martin, F.,Moir, E.M.,Morrow, J.A.,Pantling, J.,Rankovic, Z.,Smith, L.
A novel series of positive modulators of the AMPA receptor: structure-based lead optimization.
Bioorg.Med.Chem.Lett., 20:6072-6075, 2010

PubMed Abstract: Starting from lead compound 1, we demonstrate how X-ray structural data can be used to understand SAR and expediently optimize bioavailability in a novel series of AMPA receptor modulators, furnishing 5 with improved bioavailability and robust in vivo activity.

PubMed: 20817521
DOI: 10.1016/j.bmcl.2010.08.063

実験手法

X-RAY DIFFRACTION (1.8 Å)