3NXU
Crystal structure of human cytochrome P4503A4 bound to an inhibitor ritonavir
Summary for 3NXU
| Entry DOI | 10.2210/pdb3nxu/pdb |
| Related | 1TQN 1W0E 1W0F 1W0G 2J0D 2V0M |
| Related PRD ID | PRD_001001 |
| Descriptor | Cytochrome P450 3A4, DIMETHYL SULFOXIDE, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total) |
| Functional Keywords | alpha beta protein, cytochrome p450 fold, hemoprotein, monooxygenase, cytochrome p450 reductase, endoplasmic reticulum, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: P08684 |
| Total number of polymer chains | 2 |
| Total formula weight | 114106.62 |
| Authors | Sevrioukova, I.F.,Poulos, T.L. (deposition date: 2010-07-14, release date: 2010-10-20, Last modification date: 2023-09-06) |
| Primary citation | Sevrioukova, I.F.,Poulos, T.L. Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir. Proc.Natl.Acad.Sci.USA, 107:18422-18427, 2010 Cited by PubMed: 20937904DOI: 10.1073/pnas.1010693107 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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