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3NXU

Crystal structure of human cytochrome P4503A4 bound to an inhibitor ritonavir

Summary for 3NXU
Entry DOI10.2210/pdb3nxu/pdb
Related1TQN 1W0E 1W0F 1W0G 2J0D 2V0M
Related PRD IDPRD_001001
DescriptorCytochrome P450 3A4, DIMETHYL SULFOXIDE, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
Functional Keywordsalpha beta protein, cytochrome p450 fold, hemoprotein, monooxygenase, cytochrome p450 reductase, endoplasmic reticulum, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane; Single-pass membrane protein: P08684
Total number of polymer chains2
Total formula weight114106.62
Authors
Sevrioukova, I.F.,Poulos, T.L. (deposition date: 2010-07-14, release date: 2010-10-20, Last modification date: 2023-09-06)
Primary citationSevrioukova, I.F.,Poulos, T.L.
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir.
Proc.Natl.Acad.Sci.USA, 107:18422-18427, 2010
Cited by
PubMed: 20937904
DOI: 10.1073/pnas.1010693107
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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