Summary for 2V0M
Entry DOI | 10.2210/pdb2v0m/pdb |
Related | 1TQN 1W0E 1W0F 1W0G 2J0D |
Descriptor | CYTOCHROME P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, 1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZINE (3 entities in total) |
Functional Keywords | metal-binding, transmembrane, oxidoreductase, endoplasmic reticulum, drug metabolizing enzyme, ketoconazol, polymorphism, monooxygenase, p450, nadp, iron, heme, cyp3a4, membrane, microsome |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 4 |
Total formula weight | 228643.32 |
Authors | Sjogren, T.,Ekroos, M. (deposition date: 2007-05-15, release date: 2007-06-26, Last modification date: 2023-12-13) |
Primary citation | Ekroos, M.,Sjogren, T. Structural Basis for Ligand Promiscuity in Cytochrome P450 3A4 Proc.Natl.Acad.Sci.USA, 103:13682-, 2006 Cited by PubMed: 16954191DOI: 10.1073/PNAS.0603236103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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