2J0D
Crystal structure of human P450 3A4 in complex with erythromycin
Summary for 2J0D
Entry DOI | 10.2210/pdb2j0d/pdb |
Related | 1TQN 1W0E 1W0F 1W0G 2J0C |
Descriptor | CYTOCHROME P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, ERYTHROMYCIN A, ... (4 entities in total) |
Functional Keywords | polymorphism, erythromycin, monooxygenase, metal-binding, transmembrane, oxidoreductase, endoplasmic reticulum, drug metabolizing enzyme, p450, nadp, iron, heme, cyp3a4, membrane, microsome |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 112929.86 |
Authors | Sjogren, T.,Ekroos, M. (deposition date: 2006-08-02, release date: 2006-09-04, Last modification date: 2023-12-13) |
Primary citation | Ekroos, M.,Sjogren, T. Structural Basis for Ligand Promiscuity in Cytochrome P450 3A4 Proc.Natl.Acad.Sci.USA, 103:13682-, 2006 Cited by PubMed: 16954191DOI: 10.1073/PNAS.0603236103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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